Marta Tena Solsona

Dr. Marta Tena SolsonaMarta

Education

2010-2011 M.Sc. in Applied and Pharmaceutical Chemistry, Universitat Jaume I (UJI), Spain
2005-2010 B.Sc. in Chemistry, Universitat Jaume I (UJI), Spain

Academic Employment

2016- …. Postdoc, Technical University of Munich

2011-2015 Ph.D.in Chemical Science, Universitat Jaume I (UJI), Spain
PhD Thesis: “Hydrogels based on short amphipathic peptides: Self-assembly studies and applications” (European Mention)
with Prof. Escuder, B. and Prof. Miravet, J.F. and Prof Smith, D.K. (University of York, England)

Research Philosophy

After my graduation in Chemistry I obtained my masters in Pharmaceutical Chemistry and I accomplished my PhD at Universitat Jaume I (Spain) guided by Prof. B. Escuder and Prof. J.F. Miravet.

I developed my PhD work in the field of Supramolecular Chemistry, specifically with molecular gels, trying to understand the fundamentals which drive the self-assembly process and lead finally the formation of such interesting materials like hydrogels. Finding interesting applications of these nature inspired biomaterials, considering their particular advantages, is also one of our main goals and in this regard, self-assembled peptides derivatives were applied as amyloid fibrillisation models or functional organic materials including organocatalyst and sensitive stimulus hydrogels. During my PhD thesis I also had the opportunity to apply such interesting self-assembly approach to develop self-assembled multivalent heparin (anti-coagulant drug) dendritic ligands working with Prof. D.K. Smith at York University (England). Such new binders are able to operate removing the heparin in highly competitive conditions like human serum.

In most of the cases, the main part of these self-assembled systems operates under thermodynamic conditions but it has been shown that the final properties of these materials can be easily tuned by changing the self-assembly process, which means how important the thermodynamic or kinetic control of our systems is.

Focusing on that, I am currently working as a Postdoc under the supervision of Prof. Boekhoven in the Supramolecular Chemistry Group at TUM (Germany). We are trying to develop new and interesting biomaterials by means of exploring kinetically controlled self-assembly pathways. Then by pushing out of the thermodynamic equilibrium our systems we aim to cover new broad range of applications which cannot be achieved by traditional thermodynamic approaches in a similar way biomaterials perform in nature.

Publications

Emergent Catalytic Behaviour of Self-Assembled Low Molecular Weight Peptide-based Aggregates and Hydrogels
Tena-Solsona, J. Nanda, A. Chotera, G. Ashkenasy, B. Escuder
Accepted in Chem. Eur. J., 2016   DOI: 10.1002/chem.201600344

Thermodynamic and Kinetic Study of the Fibrillization of a Family of Tetrapeptides and its Application to Self-sorting. What Takes so Long?
Tena-Solsona, J. F. Miravet, B. Escuder
Chem. Mater., 2015, 27 (9), 3358

Towards Supramolecular Catalysis with Small Self-assembled Peptides
Singh, M. Tena-Solsona, J. F. Miravet, B. Escuder
Isr. J. Chem., 2015, 55 (6-7), 711

Mechanistic Insight into the Lability of Benzyloxycarbonyl (Z) Group in some N-Protected Peptides under Mild Basic Conditions
Tena-Solsona, C. Angulo-Pachón, B. Escuder and J. F. Miravet
Eur. J. Org. Chem., 2014, 3372

-Co-assembly of tetrapeptides into complex pH-responsive molecular hydrogel networks
Tena-Solsona, S. Alonso-de Castro, J.F. Miravet, B. Escuder
Mater. Chem. B, 2014, 2 (37), 6192

-Tetrapeptidic Molecular Hydrogels: Self-assembly and Co-aggregation with Amyloid
Tena-Solsona, J. F. Miravet, B. Escuder
Chem. Eur. J., 2013, 20, 1023

Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles
F. Miravet, B. Escuder, M.D. Segarra-Maset, M.Tena-Solsona, I. W. Hamley, A. Dehsorkhib, V. Castelletto.
Soft Matter, 2013, 9, 3558