DNA nanotechnology and peptides combined to instruct cells

The recent work published in Nature Communications is highlighted by Northwestern’s school of engineering:

A groundbreaking advancement in materials from Northwestern University could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson’s disease, Alzheimer’s disease, arthritic joints or any other condition requiring tissue regeneration, according to a new study.

Source

 

Nature Materials publishes our work on Energy Landscapes

The work of Faifan and me at Northwestern University got published in Nature Materials! In this work, we have studied the energy landscapes of peptide amphiphile assemblies and how to navigate through such landscapes. Such knowledge is important because we found that the position in the landscape determines the material properties, including toxicity and ability to promote cell growth. In other words, one molecule in the exact same environment can either be toxic or not depending on its position in its energy landscape.

More here:
Tantakitti, T; Boekhoven, J; Wang, X; Kazantsev, R; Yu, T; Li, J; Zhuang, E; Zandi, F; Ortony, J; Newcomb, C; Palmer, L; Gajendra; S, de la Cruz, M; Schatz, G; Stupp, S;
“Energy landscapes of supramolecular systems determine their function”

Science publishes our active materials paper

The research that Wouter Hendriksen and I worked on at TU Delft got published in Science! In this work, we push supramolecular materials out of equilibrium by means of a chemical fuel. It turned out that the active materials we form that way are transient and have a tunable lifetime. Moreover, the materials are self-regenerating as long as sufficient fuel is present. And to our surprise, we found beautiful dynamic fibres that are both growing and collapsing at the same time. See move below:

Boekhoven, J;* Hendriksen,* Koper, B; W; Eelkema, R; van Esch, J;
Transient assembly of active materials fueled by a chemical reaction
2015, Science
With perspective by van der Zwaag and Meijer:
Fueling connections between chemistry and biology”
2015Science

Millions Awarded to Northwestern for Energy Research

Two Energy Frontier Research Centers (EFRCs) at Northwestern University will continue to receive multimillion-dollar funding from the U.S. Department of Energy (DOE) for projects designed to accelerate the scientific breakthroughs needed to build a new 21st-century energy economy.

The Northwestern University Center for Bio-Inspired Energy Science (CBES) Center will receive $12 million over 4 years, and the Argonne-Northwestern Solar Energy Research (ANSER) Center will receive $15.2 million over 4 years.

Samuel I. Stupp, director of Northwestern’s CBES, said the center will use the funds to develop artificial materials, inspired by biological systems, that can change the way we convert and use energy. Stupp is the Board of Trustees Professor of Materials Science and Engineering, Chemistry and Medicine at Northwestern.

– See more at: http://www.northwestern.edu/newscenter/stories/2014/06/millions-awarded-to-northwestern-for-energy-research.html#sthash.uW3j0Pts.dpu

 

Christina’s paper on “cell death or survival instructed by supramolecular cohesion” highlighted by phys.org

syntheticpepSynthetic peptides use the force to influence cell survival

(Phys.org) —Peptide amphiphiles (PAs) are an emerging class of molecules that can be designed for novel therapies in advanced medicine. They are designed with structural regions that allow them to spontaneously assemble into large complex structures like nanofibers (fibers with diameters of approximately 10 nanometers). Researchers in this study investigated how positively charged PAs interact with cells when water-hating properties and hydrogen bonding (a force that holds the nanofibers together) are altered. Using the BioCARS beamline 14-BM-C at the U.S. Department of Energy Office of Science’s Advanced Photon Source (APS) to collect data, they evaluated forces within the biological assemblies.

Read more at: http://phys.org/news/2014-05-synthetic-peptides-cell-survival.html